Professor Pål Falnes leads the “Biological methylation” research group at the Department of Biosciences, University of Oslo, Norway. His group is also part of the recently launched Centre of Excellence CRESCO (Centre for Embryology and Healthy Development). The cellular macromolecules DNA, RNA and protein are subject to numerous modifications, including methylations and hydroxylations. Such modifications typically have optimizing or regulatory roles, such as the epigenetic modifications of DNA and chromatin proteins. Professor Falnes’s research has primarily been aimed at identifying novel human enzymes involved in the introduction and removal of such modifications, as well as to address their biological significance. The studies have encompassed methyltransferases (MTases) and hydroxylases involved in modifying tRNA and protein, as well as demethylases responsible for removing deleterious methyl lesions from DNA.