Jenny Mjösberg
Assistant professor at the Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
Jenny Mjösberg is Assistant Professor and group leader at the Center for Infectious Medicine (CIM) at Karolinska Institutet in Stockholm. She earned her PhD in reproductive immunology at Linköping University in 2010 and during her Post-Doc period in the laboratory of Hergen Spits at the Academic Medical Center in Amsterdam, she opened a novel field in immunology with the identification of two novel subsets of human innate lymphoid cells (ILC1 & 2).
Since 2013, research in her own lab at CIM is focused on the importance of human ILCs in mucosal homeostasis and inflammation, mainly the lung and gastrointestinal tract. Importantly, Mjösberg recently provided the first transcriptional characterization of human ILCs on the single-cell level. These studies have revealed previously unknown heterogeneity among human ILCs and a plethora of characteristics and regulatory mechanisms that control the function of specific ILC subsets. Her group aims at understanding the role of ILCs in gastrointestinal disease, including graft-versus-host disease, liver fibrosis, colorectal cancer and inflammatory bowel disease for the development of novel therapeutic concepts.
Selected publications
  • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
    Jochem H Bernink, Charlotte P Peters, Marius Munneke, Anje A te Velde, Sybren L Meijer, Kees Weijer, Hulda S Hreggvidsdottir, Sigrid E Heinsbroek, Nicolas Legrand, Christianne J Buskens, Willem A Bemelman, Jenny M Mjösberg & Hergen Spits Nature Immunology, Volume14, 221–229 (2013)
  • Composition of innate lymphoid cell (ILC) subsets in the human skin: Enrichment of NCR+ ILC3 in psoriatic skin inflammation.
    Teunissen MBM, Munneke M, Bernink J, Spuls PI, Res PCM, te Velde A, Cheuk S, Brouwer MWD, Menting SP, Eidsmo L, Spits H, Hazenberg MD and Mjösberg J.
    J Invest Dermatol, Volume 134, 2351-2360 (2015)
  • The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA-sequencing.
    Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, Sandberg R, Mjösberg J.
    Nature Immunology, Volume 4, 451-460 (2016)
  • Prostaglandin E2 suppresses human group 2 innate lymphoid cell function.
    Maric J, Ravindran A, Mazzurana L, Björklund ÅK, Van Acker A, Rao A, Friberg D, Dahlén SE, Heinemann A, Konya V, Mjösberg J.
    J Allergy Clin Immunol, Volume 141, 1761-1773 (2018)
  • Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation.
    Maric J, Ravindran A, Mazzurana L, Van Acker A, Rao A, Kokkinou E, Ekoff M, Thomas D, Fauland A, Nilsson G, Wheelock CE, Dahlén SE, Ferreirós N, Geisslinger G, Friberg D, Heinemann A, Konya V, Mjösberg J.
    J Allergy Clin Immunol, Volume 143, 2202-2214 (2019)